【參考文獻】
1 Bosken CH,Harks J, Gatter K,et al. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocyto chemistry〔J〕.Am Re Respir Dis,1992;145:911.
2 Hogg JC. Chronic obstructive pulmonary disease: an overview of pathology and pathogenesis〔J〕. Novartis Found Symp,2001;234:419.
3 Churg A, Dal J, Tai H, et al. Tumor necrosis factorα is central to acute cigarette smokeinduced inflammation and connective tissue breakdown〔J〕. Am J Respir Crit Care Med, 2002;166(6):84954.
4 Sarah VC, Duncan FR, Pallav S, et al. Inspaired inhibition by dexamethasone of cytokine realease by alveolar macrophages from patients with chronic obstructive pulmonary disease〔J〕. Am J Respir Crit Care Med,2003;167:2431.
5 Retamales I, Elliott WM, Meshi B,et al. Amplification of inflammation in emphysema and its association with latent adenoviral infection〔J〕.Am J Respir Crit Care Med,2001;164(3):46973.
6 Lapperre TS, Posrma DS,Gosman MM,et al. Relation between duration of smoking cessation and bronchial inflammation in COPD〔J〕.Throax,2006;61(2):11521.
7 Verhoeven GT, Garrelds IM, Hoogsteden HC,et al. Effects of fluticasone propionate inhalation on level so far arachidonic acid metabolites in patient swit chronic obstructive pulmonary disease〔J〕. Mediators Inflamm, 2001;10(1):2266.
8 LI YH, Brauner A, Jonsson B, et al. Inhibition of macrophage proinflammatory cytokine express by steroids and recombinant IL10〔J〕. Biol Neonate, 2001;80(2):12432.
9 van der Palen J, Monninkhof E, van der Valk P,et al. Cost effectiveness of inhaled steroid withdrawal in outpatients with chronic obstructive pulmonary disease〔J〕.Thorax, 2006;61(1):2933.
10 Calverley PM,Boonsawat W,Cseke Z,et al.Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease〔J〕. Eur Respir J,2003;22(6):9129.
11 Gagnon YM, Levy AR, Spencer MD,et al. Economic evaluation of treating chronic obstructive pulmonary disease with inhaled corticosteroids and longacting beta2 agonists in a health maintenance organization〔J〕. Respir Med,2005;99(12):153445.
12 Nicho KL, Margolis KL,Wuorenma J,et al.The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community〔J〕.N Engl J Med,1994;331:77884.
13 Gamble E,Grootendorst DC,Brightling CE,et al. Antiinflammatory effects of the phosphon sphodiesterase4 inhibitor cilomilast (Airflo)in chronic obstructive pulmonary disease〔J〕.Am J Resp Crit Care Med, 2003;168:97682.
14 Rennard SI, Schachter N, Strek M, et al.Cilomilast for COPD:results of a 6month, placebocontrolled study of a potent, selective inhibitor of phosphodiesterase 4〔J〕.Chest,2006;129(1):5666醫(yī).學(xué)全.在.線網(wǎng)站quanxiangyun.cn.
15 Corbel M, Noella G, Jerome L,et al.The selective phosphodiesterase 4 inhibitor RP73401 reduced matrix metalloproteinase 9 activity and transforming growth factorβ release during acute lung injury in mice: the role of the balance between tumor necrosis factorα and interleukin10〔J〕.Pharm Exp Ther,2002;301(1):25865.
16 Alexandre T, Thomas H,Keller,et al. CGH2466,a combined adenosine receptor antagonist, p38 mitogenactivated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo antiinflammatory activities〔J〕. Brit J Pharm,2005;144: 100210.
17 Back M. Functional characteristics of cysteiny 12 leukotriene receptor subtypes〔J〕.Life Sci,2002;71:61122.
18 Dempsey OJ,Kennedy G, Lipworth BJ.Comparative efficacy and antiinflammatory profile of once daily therapy with leukotrieneant agonistor lowdose inhaled corticoster oid in patients with mild persistent asthma〔J〕.J Allergy Clin Immunol,2002;109(1):6874.
19 Zühlke F,Kanniess K,Richter D,et al.Montelukast attenuates the airway response to hypertonic saline in moderatetosevere COPD〔J〕.Eur Respir J,2003;22:92630.
20 Ola M, Boveri B, Carlucci P, et al. Lung function improvement in smoker suffering from COPD with zafirlukast,a CysLT1 receptor antagonist〔J〕.Pulm Pharmacol Ther,2000;13:3015.
21 Rubinstein I,Kumar B, Schriever C. Longterm montelukast therapy in moderate to severe COPDa preliminary obvervation〔J〕. Respir Med,2004;98(2):1348.
22 De Boer WI. Cytokines and therapy in COPD: a promising combination〔J〕. Chest,2002;121(3):20918.
23 Spond J, Case N, Chapman RW,et al. Inhibition of experimental acute pulmonary inflammation by pirfenidone〔J〕.Pulm Pharmacol Ther,2003;16(4):20714.
24 Angshu BH, Terence AK, Rajmone JS,et al. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations〔J〕. Thorax,2000;55:11420.
25 Delacourt C,Herigault S,Delcau X, et al. Protection against acute lung injury by intravenous or intratracheal pretreatment with EPIHEN4,a new potent neutrophil elastase inhibitor〔J〕.Respir Cell Mol Boil,2006:2907.
26 Siemiatkowski A,Kosel J. Adhesion molecules and their rloe in organ response after traumol〔J〕.Pol Merkur Lekarski,2001;10(60):4658.
27 Basyigit I, Yildiz F, Ozkara SK, et al. The effect of clarithromycinon inflammatory markers in chronic obstructive pulmonary disease: preliminary data〔M〕.Ann Pharmacother,2004;38(9):14005.