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醫(yī)學(xué)免費論文:血脂康對高脂血癥患者血脂、血管內(nèi)皮功能及頸動脈內(nèi)膜中層厚度的影響
【摘要】 目的：觀察血脂康對高脂血癥患者血脂水平、血管內(nèi)皮功能及頸動脈內(nèi)膜中層厚度(IMT)的影響。方法：110例高脂血癥患者隨機分為觀察組和對照組，各55例，觀察組予血脂康膠囊1次0.6g，1天2次，口服，12周;對照組予普伐他汀片1次20mg，1天1次，口服，12周。測定兩組治療前后血甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDLC)、高密度脂蛋白膽固醇(HDLC)、血內(nèi)皮素(ET)、一氧化氮(NO)水平及頸動脈內(nèi)膜中層厚度 (IMT)。結(jié)果：與治療前比較，治療后兩組TG、TC、LDLC降低，HDLC升高，差異均有統(tǒng)計學(xué)意義(P<0.05);兩組治療后ET降低，NO升高，與治療前比較差異有統(tǒng)計學(xué)意義(P<0.05);兩組治療后IMT降低與治療前比較也有統(tǒng)計學(xué)意義(P<0.05)。觀察組與對照組比較，治療后TG、TC、LDLC降低及HDLC升高均無統(tǒng)計學(xué)意義(P>0.05)，但ET降低和NO升高差異有統(tǒng)計學(xué)意義(P<0.05);兩組IMT比較無統(tǒng)計學(xué)意義(P>0.05)。結(jié)論：血脂康1天1.2g調(diào)脂、逆轉(zhuǎn)頸動脈內(nèi)膜中層厚度的效果與普伐他汀1天20mg相同，但改善血管內(nèi)皮功能作用強于普伐他汀。
【關(guān)鍵詞】 高脂血癥 血脂康 內(nèi)皮素 一氧化氮 頸動脈內(nèi)膜中層厚度
Effect of Xuezhikang on Blood Lipid Levels,Endothelial Function and Carotid Intimamedia Thickness in Patients with Hyperlipidemia WANG Min,YAO Qiang,WANG Shisheng.Department of Cardiology,Zhejiang Traditional Chinese Medicine and Western Medicine Hospital,Hangzhou (310003) China
Abstract Objective:To study the effects of Xuezhikang(XZK) on blood lipid levels,endothelial function and carotid intimamedia thickness in patients with hyperlipidemia.Methods:A total of 110 patients with hyperlipidemia were randomly allocated to observation group (XZK 1.2g/day 12 week,n=55) and control group (pravachol 20 mg/day 12 week,n=55).Serum levels of triglyceride(TG),total cholesterol(TC),lowdensity lipoproteincholesterol(LDLC),highdensity lipoproteincholesterol(HDLC),endothelin (ET),and nitric oxidate (NO) were determined and carotid intimamedia thickness(IMT) was measured before and after treatment in both groups.Results:After treatment,TG,TC,and LDLC were significantly decreased and HDLC increased in both groups(P<0.05);ET markedly decreased and NO increased in both groups(P<0.05);Carotid IMT significantly decreased in both groups(P<0.05),as compared with those before treatment.Except for the changes of ET and NO(P<0.05),the difference of other parameters did not reach a significant value between the 2 groups (P>0.05).Conclusion:XZK (1.2g/day) can correct the abnormal blood lipids,improve the endothelial function and reverse carotid IMT in patients with hyperlipidemia,with an equivalent effect to pravachol(20 mg/day) in adjusting blood lipids and reversing carotid IMT,but a stronger effect in improving endothelial function醫(yī).學(xué)全.在.線網(wǎng)站quanxiangyun.cn.
Key words hyperlipidemia Xuezhikang endothelin nitric oxide carotid intimamedia thickness
高脂血癥可致血管內(nèi)皮功能異常，甚至高脂血癥患者即使在沒有明確的動脈粥樣硬化形成時即有內(nèi)皮功能障礙,調(diào)脂治療可使之明顯改善[1，2]。血脂康是采用生物技術(shù)從特制紅曲中提煉精制而成的血脂調(diào)節(jié)劑,已經(jīng)證實可以有效并安全調(diào)節(jié)血脂異常 [3]。本研究旨在觀察血脂康對高脂血癥患者血脂、血一氧化氮(NO)、內(nèi)皮素(ET)水平及頸動脈內(nèi)膜中層厚度(IMT)的影響，探討其血管內(nèi)皮保護功能及逆轉(zhuǎn)頸動脈IMT作用。
1 臨床資料
