| 公開(公告)號 | CN1196712C |
| 公開(公告)日 | 2005.04.13 |
| 申請(專利)號 | CN01106757.8 |
| 申請日期 | 2001.02.21 |
| 專利名稱 | 一種類人膠原蛋白及其生產(chǎn)方法 |
| 主分類號 | C07K14/78 |
| 分類號 | C07K14/78;C12P21/02 |
| 分案原申請?zhí)? | |
| 優(yōu)先權 | |
| 申請(專利權)人 | 范代娣 |
| 發(fā)明(設計)人 | 范代娣 |
| 地址 | 710075 陜西省西安市西北大學化工系 |
| 頒證日 | |
| 國際申請 | |
| 進入國家日期 | |
| 專利代理機構 | 西安新思維專利事務所有限公司 |
| 代理人 | 李罡 |
| 國省代碼 | 陜西;61 |
| 主權項 | 一種類人膠原蛋白，其特征在于：其序列如下HDPVVLQRRDWENPGVTQLNRHLAHAHPPFASDHPMGAPGPAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAHGPAGALGAHGPAGPLGPAGPPGSAGAPGAHGPAGPLGAHGPAGPLGAHGPAGPLGAHGPAGPLGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAHGPAGPLGAHGPAGPLGAHGPAGPLGAHGPAGPLGAPGPAGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAHGPAGPLGAHGPAGPLGAHGPAGPLGAHGPAGPLGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAPGPAGPPGSAGAPGPPGAHGPAGPLGAHGPAGPLGAHGPAGPLGAMGAPGATGLSAGATHGLVTCGL，所述結構為三鏈、三螺旋結構，其核酸長度為1071bp。 |
| 摘要 | 本發(fā)明公開一種類膠原蛋白及通過基因工程菌生產(chǎn)類膠原蛋白的方法。其類人膠原蛋白的生產(chǎn)方法包括：類人膠原蛋白的工程菌的構建；將工程菌的發(fā)酵培養(yǎng)；再經(jīng)類人膠原蛋白的誘導及表達，提純，獲得目的蛋白。該方法獲得的重組蛋白在單細胞內(nèi)的表達高，其類膠原蛋白為螺旋結構，異于動物體原蛋白的交叉結構，因此它具有很好的可加工性而不改變其分子量，因此類人膠原蛋白可加工成手術縫合線、人工皮膚、膠片余層，人工器官涂層等，也可與鹵化銀、染料等結合形成具有優(yōu)良表面粘性的涂料。 |
| 國際公布 |
